Hepatitis B and C represent the most significant infectious risks in the tattoo industry. Preventing transmission of these viruses is a fundamental responsibility of every artist and studio owner. Hepatitis B (HBV) is extraordinarily resilient. The virus can survive in dried blood on work surfaces for up to 7 days. Virus concentration in blood is very high, making even microscopic amounts potentially infectious. Hepatitis C (HCV) is more fragile than HBV but remains a major risk. It can survive on surfaces for up to 3 weeks under optimal conditions. The absence of a vaccine makes prevention through correct practices the only protection. Essential prevention measures include: exclusive use of single-use equipment for any element contacting blood (needles, cartridges, ink containers, gloves). Autoclave sterilization of reusable equipment (metal grips, if used) is mandatory. Autoclaving must follow validated protocols with sterilization indicators at each cycle. Work surfaces must be covered with single-use barriers (cling film or dedicated covers) and disinfected with approved virucidal products between clients. Disinfectants must be specifically effective against HBV and HCV. Complete HBV vaccination (3 doses) is strongly recommended for all artists. Antibody titer verification after vaccination confirms protection. Boosters may be needed if titer decreases. Client screening through medical questionnaires identifies risk factors but does not eliminate risk. Universal precautions must be applied with every client, as many carriers are asymptomatic. In case of an exposure incident (accidental needlestick with contaminated needle, blood splash on mucous membranes), post-exposure protocol must be initiated immediately. Time to medical intervention directly influences prophylaxis efficacy.